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申请/专利权人：苏州吉因加生物医学工程有限公司;北京吉因加医学检验实验室有限公司

摘要：本发明提供了一种肝癌细胞特异性甲基化标志物及其应用。涉及生物医学领域，通过对这些甲基化标志物进行片段水平的甲基化信号检测，可实现对受检人群的肝癌患癌风险筛查，在保证低假阳性率下，显著提升肝癌患者的检出率。此外，通过靶向甲基化测序的方式，有望进一步提高肝癌的早筛性能、实现提供精准、低成本、便捷好用的肝癌早期筛查，从而提高肝癌患者的生存获益并降低医疗负担。

主权项：1.一种肝癌甲基化标志物，其特征在于，所述甲基化标志物包括以下中的一个或多个：chr1:40105051-40105187；chr1:41284184-41284510；chr1:47695423-47696061；chr1:50889588-50889711；chr1:87617604-87617917；chr1:110626210-110626376；chr1:110626438-110626701；chr1:118149765-118150390；chr1:119526993-119527583；chr1:119543077-119543454；chr1:147775138-147775889；chr1:147790503-147790807；chr1:153652281-153652419；chr1:156814999-156815356；chr1:171810392-171811744；chr1:197881741-197882163；chr1:197888092-197888350；chr2:1746781-1748873；chr2:19551736-19551790；chr2:19556760-19556860；chr2:45159552-45159773；chr2:45232106-45232392；chr2:63278887-63278944；chr2:63279378-63279598；chr2:63279917-63280030；chr2:63280968-63281638；chr2:66809366-66809448；chr2:73147183-73147433；chr2:87016406-87016861；chr2:87018329-87018715；chr2:87884057-87884168；chr2:106681787-106681946；chr2:111876971-111877258；chr2:112123761-112124041；chr2:114034275-114034443；chr2:114034646-114034958；chr2:119067627-119068276；chr2:175207220-175207450；chr2:200333307-200333426；chr2:203036187-203036287；chr3:147109108-147109338；chr3:181443776-181444047；chr4:3371520-3371567；chr4:54969963-54970418；chr4:54975677-54976202；chr4:76555347-76555870；chr4:155662743-155662863；chr5:2755158-2755241；chr5:42951575-42951967；chr5:42991981-42992075；chr5:42994823-42995380；chr5:92908819-92908989；chr5:92932393-92932576；chr5:92932727-92932805；chr5:92935126-92935197；chr5:139047620-139047740；chr5:140306333-140306817；chr6:3230145-3230453；chr6:6007259-6008064；chr6:10381523-10381727；chr6:26251817-26252266；chr6:27647843-27647971；chr6:28175078-28175438；chr6:29943349-29943528；chr6:106957902-106958141；chr7:23507540-23507707；chr7:76139449-76139489；chr7:96636596-96636690；chr7:96651453-96651668；chr7:96652222-96652482；chr7:129417903-129418079；chr7:149112129-149112328；chr7:150786209-150786462；chr8:11541006-11541189；chr8:11554732-11555107；chr8:29387217-29387495；chr8:49292486-49292620；chr8:102503944-102504032；chr8:102506421-102506795；chr8:144509486-144509901；chr8:144510208-144510445；chr9:99449036-99449367；chr9:117149582-117150405；chr9:126777284-126777363；chr9:129884948-129885519；chr9:136654342-136654632；chr10:88730767-88731375；chr10:102997326-102997643；chr10:118891628-118891717；chr10:118900199-118900294；chr11:314044-314114；chr11:9025986-9026252；chr11:57250204-57250848；chr11:69517005-69517211；chr11:69517700-69517971；chr12:49366489-49366539；chr12:58021140-58021347；chr12:103696091-103696309；chr12:109162703-109162838；chr13:28545186-28545377；chr13:28674034-28674073；chr13:76211191-76211486；chr13:100643270-100643520；chr14:37050835-37051197；chr14:37125653-37126113；chr14:61109281-61109399；chr14:101923185-101923503；chr15:37171903-37172010；chr15:37172356-37172479；chr15:41805530-41806125；chr15:65186607-65186912；chr15:65360366-65360499；chr15:66546674-66546860；chr15:75251468-75251807；chr15:76635709-76635762；chr15:83951913-83952088；chr16:28891407-28891906；chr16:29887967-29888305；chr16:54324210-54324471；chr17:5000370-5000922；chr17:27044509-27045031；chr17:43037427-43037587；chr17:43047405-43047453；chr17:46796854-46797292；chr17:70112858-70113008；chr17:75368620-75368751；chr17:75370803-75371003；chr18:3499671-3499814；chr18:28621773-28622247；chr19:11532147-11532223；chr19:21646251-21646726；chr19:36736389-36736708；chr19:38182803-38183461；chr19:38700349-38700577；chr19:46001663-46002248；chr19:48984379-48984451；chr19:50553780-50554540；chr19:51830195-51830717；chr19:52206853-52206957；chr19:57182976-57183079；chr19:58520758-58521322；chr20:50720871-50721407；chr21:26934241-26934805；chr21:28340159-28340237；chr22:37731203-37731495。

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