买专利卖专利找龙图腾，真高效！ 查专利查商标用IPTOP,全免费！专利年费监控用IP管家,真方便！

申请/专利权人：中国医学科学院血液病医院(中国医学科学院血液学研究所)

摘要：本发明提供了一种基于SNP高通量测序技术检测血液系统肿瘤17号染色体多种变异的组合物、试剂盒及应用。具体地，本发明筛选出了一组特定的SNPs位点组合并基于此设计了一套基于SNP高通量测序技术检测血液系统肿瘤17号染色体多种变异的方法。本发明的检测体系可将17号染色体整条染色体的各类问题一次检测达成，并形成系统的生物信息分析，达到质量保证。另外，本发明还提供了一种基于SNP高通量测序技术检测TP53基因及17号染色体异常的方法，配合常规的TP53基因探针可直接将bi‑TP53定义的所有变异异常检出。

主权项：1.一种检测血液系统肿瘤17号染色体变异的SNPs组合，其特征在于，所述SNPs组合包含SNP位点1-669，共669个SNP位点，所述SNP位点1-669的rs号依次为rs1609550、rs4313866、rs7503725、rs7502594、rs4968139、rs440920、rs4968122、rs11247568、rs2259905、rs2255157、rs28548088、rs34041110、rs7208768、rs3785967、rs3785966、rs2293067、rs7212936、rs4790291、rs7222846、rs869020、rs216219、rs12451892、rs11078231、rs9896241、rs7207322、rs12943367、rs7207565、rs404501、rs1586929、rs322939、rs224500、rs1178563、rs4790544、rs17846889、rs781831、rs9910347、rs11652928、rs12937759、rs7219205、rs2306266、rs9903172、rs2304970、rs238247、rs398635、rs2304446、rs2439938、rs9907108、rs11869909、rs2215496、rs2309451、rs967786、rs967787、rs7226028、rs7207798、rs7217729、rs59728787、rs7211386、rs7209678、rs165103、rs11078642、rs9896378、rs9911691、rs2135845、rs11651931、rs1237044、rs16956630、rs3809829、rs3829603、rs4511593、rs1641523、rs12938680、rs4791840、rs7207022、rs9898751、rs2585399、rs12051691、rs918274、rs1391768、rs8073113、rs12601253、rs9894347、rs12948724、rs739435、rs12602701、rs57669224、rs7207592、rs2302198、rs6503192、rs60987385、rs16958439、rs56318894、rs1402658、rs6503275、rs9909920、rs7222402、rs35503804、rs12939209、rs3744554、rs11078849、rs16943591、rs202306、rs4792043、rs2529870、rs4389174、rs66888421、rs9303037、rs1513747、rs2193109、rs9906083、rs28494779、rs12936714、rs12946579、rs1870584、rs4614769、rs11651853、rs16946208、rs8072823、rs11652201、rs4792288、rs7207068、rs11656122、rs12945380、rs2106794、rs8065267、rs2996025、rs7222005、rs7211194、rs1867234、rs11078199、rs62054735、rs6502327、rs12601910、rs2323221、rs9906855、rs8074518、rs7219146、rs11654940、rs9910122、rs62060155、rs17711876、rs9890475、rs55941631、rs16951087、rs1860295、rs381020、rs2954756、rs58393633、rs2649454、rs4349188、rs4792717、rs2285579、rs917609、rs1141283、rs9916706、rs10852841、rs61242604、rs3744137、rs1708627、rs12452946、rs1242486、rs747770、rs4925062、rs11655029、rs4925119、rs11078406、rs2955359、rs854776、rs2245737、rs2273027、rs28739464、rs75294224、rs11544711、rs1737939、rs78043159、rs4924987、rs12451696、rs3909258、rs8066143、rs2703781、rs4003696、rs68005414、rs4003456、rs7208434、rs8079974、rs4985936、rs4985967、rs732928、rs11204355、rs8078779、rs7217052、rs73311478、rs12601950、rs7405563、rs34192524、rs4889705、rs4889709、rs8081588、rs12942290、rs12942522、rs8081623、rs7221912、rs9901931、rs8070481、rs1403320、rs6505407、rs8072701、rs9895453、rs4063521、rs4239213、rs1242299、rs658591、rs2239911、rs11567842、rs12051648、rs4349196、rs7216404、rs8070016、rs4965415、rs9897342、rs797960、rs80063027、rs67546072、rs8071698、rs1986555、rs2628165、rs55974138、rs12150261、rs8065059、rs1906451、rs7342929、rs4795549、rs17767442、rs2940183、rs2952989、rs4795593、rs757375、rs757376、rs4795613、rs8075034、rs412018、rs757289、rs3760454、rs12950671、rs728718、rs756785、rs8079280、rs321164、rs2052412、rs2470224、rs7221198、rs9303660、rs72819138、rs7221886、rs7220791、rs4459594、rs4305127、rs719464、rs8072659、rs1844739、rs317373、rs317363、rs886358、rs6505397、rs212454、rs9891703、rs887229、rs4795978、rs8066240、rs1994089、rs772108、rs321617、rs720774、rs854682、rs1879917、rs4796224、rs12603276、rs1348389、rs8068144、rs883286、rs732770、rs12603097、rs12945602、rs712039、rs12942520、rs2688、rs2008765、rs72832261、rs62074772、rs3785462、rs9889251、rs4328474、rs16532、rs4795386、rs2517956、rs8067378、rs9915252、rs2071427、rs1901187、rs803120、rs2429547、rs4890133、rs7218303、rs1817966、rs4257256、rs1817965、rs6503609、rs2301354、rs3353、rs34761055、rs9896530、rs7211777、rs9889580、rs2271028、rs799916、rs4792984、rs939358、rs9901754、rs607000、rs1618809、rs2240226、rs8067711、rs2037958、rs62078767、rs8069583、rs9902879、rs4793152、rs2289677、rs9630726、rs2239916、rs2074291、rs1230068、rs1230069、rs1706732、rs2040844、rs7209436、rs3744457、rs713522、rs3912063、rs2696709、rs62072141、rs138418863、rs155764、rs11658976、rs197929、rs3851795、rs10514915、rs858671、rs2292865、rs4968319、rs2610367、rs8072100、rs6503796、rs13353189、rs2597166、rs2305433、rs7218563、rs7209556、rs11869101、rs9299、rs3110607、rs9904645、rs4794017、rs12936101、rs2671654、rs2671687、rs4997224、rs4793621、rs66517465、rs2303468、rs7217554、rs2075558、rs2586436、rs12452992、rs7208703、rs2240221、rs4148418、rs9895607、rs8073538、rs9899816、rs12945508、rs7222463、rs12948421、rs9303582、rs4794256、rs4239173、rs1263953、rs10432044、rs2319455、rs203031、rs1909923、rs7219072、rs867794、rs9908671、rs9901056、rs12947059、rs8069513、rs7501679、rs36111459、rs806931、rs6504822、rs4527065、rs2940636、rs12947626、rs4129719、rs8072813、rs11079110、rs7216717、rs12950566、rs2332185、rs2332186、rs72836116、rs34417064、rs8080652、rs16955329、rs12940239、rs11655949、rs244332、rs244331、rs876720、rs888206、rs7225691、rs34389697、rs6504992、rs9905725、rs1154748、rs4505399、rs4263004、rs874988、rs12948531、rs10852986、rs9915822、rs12951993、rs1838154、rs205500、rs12453004、rs7218592、rs9901116、rs11079287、rs8075882、rs2332932、rs6503817、rs12950269、rs4793921、rs2240815、rs2270097、rs6503870、rs302874、rs3826353、rs7214335、rs2333465、rs2599298、rs1376596、rs4968385、rs1554846、rs2453913、rs1292053、rs2204928、rs11657378、rs11079428、rs59159776、rs7225708、rs4986764、rs16945628、rs4968473、rs6416937、rs62069137、rs9900571、rs35384396、rs7225068、rs740698、rs58862628、rs7214124、rs6504146、rs6504149、rs2440140、rs1899634、rs4968644、rs4344、rs2955235、rs9902971、rs9906962、rs4968701、rs4968716、rs8065316、rs12936763、rs4791220、rs2869825、rs4791193、rs9912416、rs232123、rs9303489、rs7215457、rs8066775、rs230559、rs7501961、rs9915241、rs7210816、rs8080721、rs2286958、rs8072956、rs9901824、rs8065024、rs9897354、rs9894480、rs8076195、rs1808693、rs2099375、rs1974648、rs4791109、rs7208663、rs113985803、rs12943289、rs9901010、rs3760269、rs12939053、rs11077579、rs766304、rs9907696、rs9302983、rs4147313、rs2302294、rs12453921、rs12953127、rs1550828、rs333930、rs2716223、rs12453895、rs1079767、rs17690625、rs180050、rs8080944、rs7208109、rs6501388、rs4793265、rs9302919、rs2041265、rs12603695、rs12150092、rs28403073、rs8065642、rs9898150、rs8077100、rs9893624、rs1014216、rs4519368、rs2429970、rs8080960、rs12941874、rs10512580、rs2287132、rs28431115、rs11657132、rs11655269、rs7219788、rs2537985、rs11657319、rs2567520、rs34035852、rs9907475、rs4969060、rs4969061、rs7213515、rs8081010、rs35134850、rs6501644、rs790084、rs323389、rs1382940、rs8064315、rs869119、rs6501699、rs12937668、rs9912380、rs4789069、rs9906320、rs2016126、rs2683274、rs2683273、rs112996472、rs770580681、rs778823595、rs28377555、rs729405、rs4788883、rs1108355、rs8079362、rs820241、rs2053508、rs12600868、rs3760128、rs6501847、rs2084666、rs8067947、rs9900514、rs3803739、rs9892550、rs62086623、rs2286593、rs36013097、rs474589、rs11658601、rs2247814、rs2077948、rs1995755、rs374642、rs453268、rs429215、rs419126、rs4789468、rs10451228、rs4239001、rs9904097、rs2311001、rs1071664、rs12937823、rs12452576、rs584253、rs11077381、rs7225601、rs8072569、rs11653359、rs3744168、rs6501280、rs8075734、rs7208724、rs9897367、rs9897410、rs11658627、rs36023425、rs1702672、rs6565665、rs4889787、rs1285260、rs3934967、rs1561812、rs11655682、rs62074375、rs7220465、rs12603603、rs9896944、rs7225476、rs756075、rs7225755、rs2672881、rs4969331、rs55978953、rs869370、rs10445407、rs8067818、rs8076294、rs8075102、rs12452184、rs7214710、rs4513161、rs7406529、rs66670693、rs11077986、rs9914195、rs9910991、rs568762043、rs537054959、rs111487091、rs2246563、rs2246559、rs601555、rs601533、rs1011007、rs9912551、rs12950942。

全文数据：

权利要求：

百度查询： 中国医学科学院血液病医院(中国医学科学院血液学研究所) 一种基于SNP高通量测序技术检测血液系统肿瘤17号染色体多种变异的组合物、试剂盒及应用